...

(2) Set the location of MATLAB win64 folder in Syndeia.hep file - Open the Syndeia.hep file located in <Syndeia_Installation>\profiles\Syndeia folder, e.g C:\Users\<YourAccount>\IBM\Rational\Rhapsody\8.1.3x64\Share\Profiles\Syndeia\profiles\Syndeia. Set Specify the path location of win64 folder in your MATLAB installation in the value of JavaLibPath1 variable, as highlighted shown belowbelow. Save and close the Syndeia.hep file.

(3) Syndeia Settings - Set both Use MATLAB Engine API and Use existing MATLAB session to true in Syndeia's MATLAB settings after you have installed Syndeia.

File-based interaction

Syndeia continues to provide the existing file-based interaction with the MATLAB environment (like Syndeia 3.0). If you have a version of MATLAB / Simulink / Stateflow earlier than 2016b, use this mode. To use this mode, set the path to the MATLAB executable (e.g. matlab.exe on Windows) in Syndeia's MATLAB settings after you have installed Syndeia. If you do not specify the path, then the default MATLAB installed on your computer will be used. We recommend that you specify this path so there is no ambiguity in the MATLAB installation Syndeia should use, especially if you have multiple versions of MATLAB installed.

...